Mitochondrial dysfunction: impact on exercise performance and cellular aging

Exerc Sport Sci Rev. 2007 Apr;35(2):43-9. doi: 10.1249/JES.0b013e31803e88e9.


Innovative noninvasive methods open a new window on the cell in vivo. This window reveals that the tempo of mitochondrial dysfunction with age varies among muscles and in proportion to Type II muscle fiber content. Exercise training can reverse age-related dysfunction, thereby providing an intervention to slow the pace of aging and disability in the elderly.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adult
  • Cellular Senescence / physiology*
  • DNA, Mitochondrial
  • Exercise / physiology*
  • Humans
  • Mitochondria, Muscle / pathology
  • Mitochondria, Muscle / physiology*
  • Muscle, Skeletal / pathology
  • Muscle, Skeletal / physiology*
  • Sports Medicine


  • DNA, Mitochondrial