Bluetongue Virus VP4 Is an RNA-capping Assembly Line

Nat Struct Mol Biol. 2007 May;14(5):449-51. doi: 10.1038/nsmb1225. Epub 2007 Apr 8.


Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Anhydride Hydrolases / chemistry*
  • Binding Sites
  • Bluetongue virus / chemistry*
  • Crystallography, X-Ray
  • Methyltransferases / chemistry*
  • Protein Conformation
  • RNA Caps*
  • RNA Nucleotidyltransferases / chemistry*
  • RNA, Viral / metabolism


  • RNA Caps
  • RNA, Viral
  • Methyltransferases
  • mRNA (guanine(N7))-methyltransferase
  • mRNA (nucleoside-O(2'))-methyltransferase
  • RNA Nucleotidyltransferases
  • Acid Anhydride Hydrolases
  • RNA triphosphatase

Associated data

  • PDB/2JH8
  • PDB/2JH9
  • PDB/2JHA
  • PDB/2JHC
  • PDB/2JHP