Abstract
Dopamine behaves mainly as a MAO-A substrate in rodent brain, but selective inhibition of MAO-B results in an increased turning activity following L-DOPA administration in hemi-Parkinsonian rodents. Unilateral substantia nigra dopaminergic denervation results in serotonergic hyper-innervation which may increase the contribution of MAO-A in the denervated striatum. Possibly as a result of this, there was no change in striatal MAO-A activity when 95% of dopaminergic innervation was reduced by 6-hydroxydopamine, as assessed by apomorphine-induced turning activity. MAO-B as well as MAO-A may contribute to deamination of dopamine produced from L-DOPA.
MeSH terms
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Animals
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Basal Ganglia / drug effects
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Basal Ganglia / enzymology
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Basal Ganglia / physiopathology
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Brain / drug effects*
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Brain / enzymology*
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Brain / physiopathology
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Denervation
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Dopamine / metabolism
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Drug Interactions
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Levodopa / pharmacology*
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Monoamine Oxidase / drug effects
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Monoamine Oxidase / metabolism
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Monoamine Oxidase Inhibitors / pharmacology*
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Neural Pathways / drug effects
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Neural Pathways / enzymology
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Neural Pathways / physiopathology
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Oxidopamine
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Parkinsonian Disorders / drug therapy*
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Parkinsonian Disorders / enzymology*
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Parkinsonian Disorders / physiopathology
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Rats
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Rats, Sprague-Dawley
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Serotonin / metabolism
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Substantia Nigra / drug effects
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Substantia Nigra / enzymology
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Substantia Nigra / physiopathology
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
Substances
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Monoamine Oxidase Inhibitors
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Serotonin
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Levodopa
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Oxidopamine
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Monoamine Oxidase
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Dopamine