Expeditious access to unprotected racemic pyroglutamic acids

Jerry Isaacson; Cynthia B Gilley; Yoshihisa Kobayashi

doi:10.1021/jo0700225

Expeditious access to unprotected racemic pyroglutamic acids

J Org Chem. 2007 May 11;72(10):3913-6. doi: 10.1021/jo0700225. Epub 2007 Apr 7.

Authors

Jerry Isaacson¹, Cynthia B Gilley, Yoshihisa Kobayashi

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive Mail Code 0343, La Jolla, California 92093-0343, USA.

PMID: 17417909
DOI: 10.1021/jo0700225

Abstract

A series of biologically intriguing pyroglutamic acids were synthesized in racemic form by employing indole-isonitrile and ammonium acetate in the Ugi 4-center-3-component reaction of gamma-ketoacids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry
Anilides / chemistry
Indoles / chemistry
Methylation
Molecular Structure
Nitriles / chemistry
Pyrrolidonecarboxylic Acid / chemical synthesis*
Pyrrolidonecarboxylic Acid / chemistry
Stereoisomerism

Substances

Amines
Anilides
Indoles
Nitriles
Pyrrolidonecarboxylic Acid