Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature

Clin Exp Rheumatol. Jan-Feb 2007;25(1):47-53.

Abstract

Objective: To describe the occurrence of erosive arthropathy in systemic lupus erythematosus (SLE) and its relationship to anti-CCP antibodies.

Methods: Retrospective medical record review of a case series of five female patients with SLE and erosive arthropathies.

Results: The initial disease presentation in all patients was a polyarthritis. Anti-CCP antibodies were detected in 4 out of 5 (80%) patients, 2 of whom had a positive rheumatoid factor.

Conclusion: Erosive arthritis was strongly associated with the presence of anti-CCP antibodies in these patients with SLE, who presented with polyarthritis. Anti-CCP in patients with SLE may be a marker of a more severe joint disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / immunology
  • Female
  • Hand Joints / pathology*
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / immunology
  • Middle Aged
  • Peptides, Cyclic / immunology*
  • Pleural Effusion / etiology
  • Rheumatoid Factor / blood

Substances

  • Peptides, Cyclic
  • cyclic citrullinated peptide
  • Rheumatoid Factor