Watching neuronal circuit dynamics through functional multineuron calcium imaging (fMCI)

Neurosci Res. 2007 Jul;58(3):219-25. doi: 10.1016/j.neures.2007.03.001. Epub 2007 Mar 13.


Functional multineuron calcium imaging (fMCI) is a large-scale optical recording technique that monitors the spatiotemporal pattern of action potentials, all at once, from large neuron populations. fMCI has unique advantages, including: (i) simultaneous recording from >1000 neurons in a wide area, (ii) single-cell resolution, (iii) identifiable location of neurons and (iv) detection of non-active neurons during the observation period. We review herein the principle, history, utility and limitations of fMCI.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Diagnostic Imaging / history
  • Diagnostic Imaging / methods*
  • History, 20th Century
  • History, 21st Century
  • Nerve Net / physiology*
  • Neurons / physiology*
  • Synapses / physiology


  • Calcium