Development in motion: helper T cells at work

Cell. 2007 Apr 6;129(1):33-6. doi: 10.1016/j.cell.2007.03.019.


In mammals, helper T cells orchestrate defense against diverse pathogens. However, these warriors of the immune system can also result in self-inflicted injury culminating in autoimmune and allergic diseases. Recent findings--such as the discovery of the Th17 lineage--have revealed additional complexity in the fates chosen by helper T cells and have begun to reshape our view of how signaling and transcriptional networks generate appropriate and inappropriate immunity.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Lineage
  • Cytokines / immunology
  • Mice
  • Signal Transduction
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes, Helper-Inducer / cytology*
  • T-Lymphocytes, Helper-Inducer / immunology*
  • T-Lymphocytes, Helper-Inducer / metabolism
  • Th1 Cells / immunology
  • Th2 Cells / immunology
  • Transcription Factors / metabolism


  • Cytokines
  • Transcription Factors