The centrosome in neuronal development

Trends Neurosci. 2007 Jun;30(6):276-83. doi: 10.1016/j.tins.2007.04.001. Epub 2007 Apr 8.


Establishment of polarity is an essential process during proliferation, migration and differentiation in neurons, and the signaling pathways leading to polarization of the cytoskeleton are topics of intense research. One key marker for cell polarity is the centrosome, also known as the microtubule-organizing center. Recent discoveries have shown that the position of the centrosome is precisely regulated during neurogenesis, migration and differentiation, leading to the segregation of cell fate factors, efficient nucleokinesis and directed neurite outgrowth, respectively. Here, we review recent advances in the understanding of this interesting organelle and propose a model whereby centrosome position, determined by extracellular factors, directs multiple aspects of neuronal development.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Cell Movement / physiology
  • Centrosome / physiology*
  • Humans
  • Neurons / cytology
  • Neurons / physiology*
  • Spindle Apparatus / physiology*
  • Stem Cells / cytology
  • Stem Cells / physiology