Nosocomial diarrhea in the intensive care unit

Braz J Infect Dis. 2006 Dec;10(6):384-9. doi: 10.1590/s1413-86702006000600005.

Abstract

We made an epidemiological case-control study to examine risk factors for the development of diarrhea in the intensive care unit (ICU) of a public hospital in Santo André, SP, from January to October 2002. Forty-nine patients with diarrhea (cases) and 49 patients without diarrhea (controls), matched for age and gender, were included in the study. A stool culture and enzyme immunoassays for Clostridium difficile toxins A and B were performed on fecal specimens from diarrhea patients. Fourteen of them presented positive cultures for Pseudomonas aeruginosa and 22 patients presented positive ELISA for Clostridium diffícile. Nosocomial diarrhea was associated with several factors, including use of antibiotics (P=0.001), use of ceftriaxone (P=0.001), presence of infection (P=0.010) and length of hospital stay (P=0.0001).

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Toxins / analysis
  • Case-Control Studies
  • Clostridioides difficile / isolation & purification
  • Clostridium Infections / diagnosis
  • Clostridium Infections / drug therapy
  • Clostridium Infections / epidemiology*
  • Cross Infection / epidemiology*
  • Diarrhea / drug therapy
  • Diarrhea / epidemiology*
  • Diarrhea / microbiology
  • Feces / microbiology
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Intensive Care Units / statistics & numerical data*
  • Male
  • Middle Aged
  • Pseudomonas Infections / diagnosis
  • Pseudomonas Infections / drug therapy
  • Pseudomonas Infections / epidemiology*
  • Pseudomonas aeruginosa / isolation & purification
  • Risk Factors

Substances

  • Anti-Bacterial Agents
  • Bacterial Toxins