Modelling the influence of risk factors on familial aggregation of disease

Biometrics. 1991 Sep;47(3):933-45.


One often observes a familial resemblance of risk factors of disease. The following question then arises: How much familial aggregation of cases of disease would be expected because of this resemblance? This problem is attacked through a particular model where the risk is supposed to depend exponentially on the risk factors. Only pairs of relatives (father/son) are considered. The calculations are performed both with normally distributed risk factors and with particular skewed distributions. An application to coronary heart disease is given.

MeSH terms

  • Analysis of Variance
  • Blood Pressure
  • Coronary Disease / etiology
  • Coronary Disease / genetics*
  • Genetic Diseases, Inborn / epidemiology*
  • Humans
  • Hypercholesterolemia / genetics
  • Male
  • Mathematics
  • Middle Aged
  • Models, Statistical*
  • Risk Factors