Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery

Expert Rev Proteomics. 2007 Apr;4(2):273-86. doi: 10.1586/14789450.4.2.273.

Abstract

Uveal melanoma (UM) is the most frequent primary intraocular tumor in adult humans. Despite the significant advances in diagnosis and treatment of UM in the last decades, the prognosis of UM sufferers is still poor. Metastatic liver disease is the leading cause of death in UM and can develop after a long disease-free interval, suggesting the presence of occult micrometastasis. Proteomics technology has opened new opportunities for elucidating the molecular mechanism of complex diseases, such as cancer. This article will review the recent developments in biomarker discovery for UM research by proteomics. In the last few years, the first UM proteomics-based analyses have been launched, yielding promising results. An update on recent developments on this field is presented.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Biomedical Research
  • Humans
  • Melanoma*
  • Neoplasm Metastasis
  • Neoplasm Proteins / analysis*
  • Proteomics / methods*
  • Uveal Neoplasms*

Substances

  • Biomarkers
  • Neoplasm Proteins