ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)

J Thromb Haemost. 2007 Jul;5(7):1455-61. doi: 10.1111/j.1538-7836.2007.02579.x. Epub 2007 Apr 9.


Background: Numerous case-control studies have reported higher prevalence of non-O blood type among venous thromboembolism (VTE) patients than controls, but potential mechanisms or effect modifiers for the association are not fully established.

Patients/methods: Using a nested case-control design combining the Atherosclerosis Risk in Communities and the Cardiovascular Health Study cohort, ABO blood type and other VTE risk factors were measured on pre-event blood samples of 492 participants who subsequently developed VTE and 1008 participants who remained free of VTE.

Results: A total of 64.4% of cases and 52.5% of controls had non-O blood type. Among controls, mean values of factor VIIIc (FVIIIc) and von Willebrand factor among the non-O blood type group were higher than among the O group. Compared with O blood type, the age-adjusted odds ratio (OR) of VTE for non-O blood type was 1.64 (95% CI, 1.32-2.05) and was similar for the two parent studies and race groups. Further adjustment for sex, race, body mass index, diabetes mellitus and FVIIIc reduced the OR: 1.31 (95% CI, 1.02-1.68). Factor V Leiden (FV Leiden) appeared to modify the non-O blood type association with VTE in a supra-additive fashion, with an age-, sex- and race-adjusted OR of 6.77 (95% CI, 3.65-12.6) for having both risk factors.

Conclusions: Non-O blood type was independently associated with risk of VTE, and added to the risk associated with FV Leiden.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • ABO Blood-Group System*
  • Aged
  • Case-Control Studies
  • Diabetes Complications / blood
  • Diabetes Complications / etiology
  • Factor V / metabolism
  • Factor VIII / metabolism
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Risk Factors
  • Thromboembolism / blood*
  • Thromboembolism / etiology*
  • Venous Thrombosis / blood*
  • Venous Thrombosis / etiology*
  • von Willebrand Factor / metabolism


  • ABO Blood-Group System
  • factor V Leiden
  • von Willebrand Factor
  • Factor V
  • Factor VIII