Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance

Clin Exp Allergy. 1991 Sep;21(5):569-72. doi: 10.1111/j.1365-2222.1991.tb00848.x.


Twenty patients with irritable bowel syndrome due to food intolerance were randomized to either oral sodium cromoglycate or placebo in a double-blind cross-over trial. The study consisted of treatment with either sodium cromoglycate or placebo for 8 weeks, followed by the cross-over treatment for 8 further weeks. Patients were allowed to eat the offending foods during the study. Eighteen patients completed the study. Analysis of patients' diary card scores showed a statistically significant difference in favour of sodium cromoglycate. There was a long carry-over effect in the active-placebo order group. Therefore oral sodium cromoglycate seems to be a useful treatment in patients with irritable bowel syndrome and proven food intolerance.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Colonic Diseases, Functional / drug therapy*
  • Colonic Diseases, Functional / etiology*
  • Cromolyn Sodium / administration & dosage*
  • Double-Blind Method
  • Female
  • Food Hypersensitivity / complications*
  • Humans
  • Male


  • Cromolyn Sodium