The spindle-assembly checkpoint in space and time

Nat Rev Mol Cell Biol. 2007 May;8(5):379-93. doi: 10.1038/nrm2163. Epub 2007 Apr 11.


In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores--structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aneuploidy
  • Animals
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / metabolism
  • Cell Cycle Proteins / physiology
  • Genes, cdc / physiology*
  • Humans
  • Kinetochores / physiology
  • Models, Biological
  • Neoplasms / etiology
  • Neoplasms / genetics
  • Phosphotransferases / physiology
  • Spindle Apparatus / metabolism*
  • Time Factors


  • Cell Cycle Proteins
  • Phosphotransferases