Muesli with 4 g oat beta-glucans lowers glucose and insulin responses after a bread meal in healthy subjects

Eur J Clin Nutr. 2008 May;62(5):600-7. doi: 10.1038/sj.ejcn.1602747. Epub 2007 Apr 4.


Objective: To evaluate the impact of an extruded muesli product based on beta-glucan-rich oat bran on postprandial glycaemia and insulinaemia.

Subject/design: The study is divided in two series. Blood glucose and serum insulin responses were studied after subjects consuming test meals including a serving of muesli with 3 g (series 1) and 4 g (series 2) of beta-glucans, respectively. The muesli was a component in a single serving packet with muesli and yoghurt. This was served together with white wheat bread in the morning after an overnight fast. The compositions were standardized to contain 50 g available carbohydrates. As a reference meal a serving packet without beta-glucans was included. The study was performed at Applied Nutrition and Food Chemistry, Lund University, Sweden. Nineteen and thirteen healthy volunteers with normal body mass index were recruited for series 1 and 2, respectively.

Results: Muesli with 3 g of beta-glucans, included in a mixed bread meal, gave no significant differences in glycaemic response compared to a reference meal without muesli and beta-glucans. In contrast, muesli with 4 g of beta-glucans significantly (P<0.05) lowered the glucose and insulin responses compared to the reference meal.

Conclusions: Muesli enriched with 4 g of beta-glucans reduces postprandial glucose and insulin levels to a breakfast based on high glycaemic index products. A total of 4 g of beta-glucans from oats seems to be a critical level for a significant decrease in glucose and insulin responses in healthy people.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Area Under Curve
  • Avena / chemistry*
  • Blood Glucose / analysis
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Bread
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Edible Grain
  • Fasting
  • Female
  • Glycemic Index*
  • Humans
  • Insulin / blood*
  • Male
  • Postprandial Period
  • Viscosity
  • beta-Glucans / pharmacokinetics*


  • Blood Glucose
  • Insulin
  • beta-Glucans