Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Nov;150(2):191-204. doi: 10.5507/bp.2006.028.

Abstract

Background: Chemokines and chemokine receptors are major mediators of leukocyte trafficking into the sites of the immune response. They participate in defence against microbial infection, in Th1/Th2 polarization of the immune response, allograft rejection and angiogenesis/angiostasis as well as in tumorigenesis and metastasis. To date, several functional polymorphisms of chemokine and chemokine receptor genes have been discovered that are able to deregulate chemokine system and, therefore, they may interfere with the pathogenesis of a large number of inflammatory and other diseases. In this review we focus on the known polymorphisms of two chemokines: CCL2, CCL5 and their corresponding receptors (CCR2, CCR5) and we also discuss their associations with susceptibility and progression to selected immune-mediated diseases.

Methods and results: Based on relevant literature this article gives a short overview of case-control and family studies regarding effect of the genetic factors on diseases such as coronary artery disease, systemic lupus erythematosus, diabetes mellitus, lung diseases and others.

Conclusion: Recent advance in the identification of chemokine genetic background of the diseases could provide opportunity for pharmacological treatment. However, we need more information about posttranscriptional events to understand functional relevance of polymorphisms and to discovery new avenues to blocking disease development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chemokine CCL2 / genetics*
  • Chemokine CCL5 / genetics*
  • Chemokine CCL5 / immunology
  • Chemokine CCL5 / physiology
  • Humans
  • Polymorphism, Genetic*
  • Receptors, CCR2 / genetics*
  • Receptors, CCR2 / immunology
  • Receptors, CCR2 / physiology
  • Receptors, CCR5 / genetics*
  • Receptors, CCR5 / immunology
  • Receptors, CCR5 / physiology

Substances

  • Chemokine CCL2
  • Chemokine CCL5
  • Receptors, CCR2
  • Receptors, CCR5