Inhibition of cytochrome P-450 with 2-diethylamino-ethyl-2,2-diphenylpropylacetate (SKF-525A) reduces immunotoxicity of chlorinated carbohydrates

Bull Exp Biol Med. 2006 Sep;142(3):324-6. doi: 10.1007/s10517-006-0357-z.
[Article in English, Russian]

Abstract

Experiments on outbred albino rats showed that single intraperitoneal injection of cytochrome P-450 inhibitor 2-diethylaminoethyl-2,2-diphenylpropylacetate (SKF-525A) in a dose of 50 mg/kg before acute poisoning with 1,2-dichloroethane and trichloroethane in a dose of 1.0 LD(50), metabolized in the body to compounds with higher toxicity (the phenomenon of "lethal synthesis") reduced their immunotoxicity by decreasing the formation of their biotransformation products.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antibody Formation / drug effects
  • B-Lymphocytes / immunology
  • Cytochrome P-450 Enzyme Inhibitors*
  • Cytotoxicity Tests, Immunologic
  • Enzyme Inhibitors / pharmacology*
  • Ethylene Dichlorides / pharmacokinetics*
  • Ethylene Dichlorides / toxicity
  • Female
  • Immunoglobulin M / biosynthesis
  • Male
  • Proadifen / pharmacology*
  • Rats
  • Spectrophotometry
  • Spleen / immunology
  • Th1 Cells / immunology
  • Trichloroethylene / pharmacokinetics*
  • Trichloroethylene / toxicity

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Ethylene Dichlorides
  • Immunoglobulin M
  • Trichloroethylene
  • ethylene dichloride
  • Proadifen