Endonasal endoscopic resection and radiotherapy in olfactory neuroblastoma: our experience

Head Neck. 2007 Sep;29(9):845-50. doi: 10.1002/hed.20610.


Background: Our aim was to evaluate the efficacy of a bimodal method of treatment consisting in endoscopic resection followed by radiotherapy in patients with olfactory neuroblastoma (ON).

Methods: This is a retrospective review on 10 patients with ON treated at a tertiary referral center. All the patients were treated with endonasal endoscopic resection, and 1 refused postoperative radiotherapy.

Results: No mortality was observed. Local tumor control was obtained in all the patients. Follow-up ranged from 15 to 79 months (median, 37 months). One patient developed a regional recurrence and for this was treated with bilateral, modified type III radical neck dissection plus radiotherapy on the neck. All patients regained a good quality of life after the treatment.

Conclusions: This method of treatment causes minimal injury to the patients, reduces side effects, and improves the quality of life of those with olfactory neuroblastoma.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Endoscopy / methods*
  • Esthesioneuroblastoma, Olfactory / radiotherapy*
  • Esthesioneuroblastoma, Olfactory / surgery*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nasal Cavity
  • Nose Neoplasms / radiotherapy*
  • Nose Neoplasms / surgery*
  • Quality of Life
  • Radiotherapy, Adjuvant
  • Retrospective Studies