Cellular and molecular pathogenesis of type 1A diabetes

Cell Mol Life Sci. 2007 Apr;64(7-8):865-72. doi: 10.1007/s00018-007-6469-4.


Type 1A diabetes is an organ-specific autoimmune disease resulting from destruction of insulin-producing pancreatic beta-cells. The main susceptibility genes code for polymorphic HLA molecules and in particular alleles of class II MHC genes (DR, DQ and DP). Polymorphisms of individual genes outside the MHC also contribute to diabetes risk but recent evidence suggests that there are additional non-HLA genes determining susceptibility linked to the MHC. It is now possible using genetic and autoantibody assays to predict the development of type 1A diabetes in the majority of individuals, and trials of diabetes prevention are underway.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / prevention & control
  • Genes, MHC Class II
  • Genetic Predisposition to Disease*
  • HLA Antigens / genetics
  • Humans
  • Insulin-Secreting Cells / immunology
  • Polymorphism, Genetic
  • Risk Factors


  • HLA Antigens