Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy

J Mol Med (Berl). 2007 Aug;85(8):797-810. doi: 10.1007/s00109-007-0183-4. Epub 2007 Apr 12.


Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiomegaly / metabolism
  • Cardiomegaly / physiopathology*
  • Cardiovascular Physiological Phenomena*
  • Cardiovascular System / metabolism
  • Guanylate Cyclase / metabolism
  • Guanylate Cyclase / physiology*
  • Humans
  • Models, Biological
  • Natriuretic Peptide, C-Type / metabolism
  • Natriuretic Peptide, C-Type / physiology
  • Receptors, Atrial Natriuretic Factor / metabolism
  • Receptors, Atrial Natriuretic Factor / physiology*
  • Signal Transduction*


  • Natriuretic Peptide, C-Type
  • Guanylate Cyclase
  • Receptors, Atrial Natriuretic Factor
  • atrial natriuretic factor receptor B