Biotechnological production of spider-silk proteins enables new applications

Macromol Biosci. 2007 Apr 10;7(4):401-9. doi: 10.1002/mabi.200600255.


The outstanding mechanical properties of spider silks have motivated many researchers to establish biotechnological production techniques which are necessary to provide sufficient amounts of silk proteins for industrial applications. Based on recent developments in genetic engineering, two strategies for the recombinant production of spider-silk proteins have been established which are discussed in detail. Further, protein-design strategies are described, enabling the combination of silk properties with additional biological, chemical, or technical features. We highlight the potential of engineered and recombinantly-produced spider-silk proteins to provide the basis for a new generation of biomaterials.

Publication types

  • Portrait
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Biotechnology* / trends
  • Protein Engineering
  • Recombinant Proteins / chemistry*
  • Recombinant Proteins / genetics
  • Silk / chemistry*
  • Silk / genetics
  • Spiders / chemistry*
  • Spiders / genetics


  • Biocompatible Materials
  • Recombinant Proteins
  • Silk