Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum)

J Pharm Pharmacol. 2007 Apr;59(4):591-6. doi: 10.1211/jpp.59.4.0015.

Abstract

Blueberries are among the edible fruits that are recognized best for their potential health benefits. The crude extract from Vaccinium corymbosum was assessed in anti-inflammatory and antinociceptive models. The crude hydroalcoholic extract was administered orally at doses of 100, 200 or 300 mg kg (-1) for all the assays. In the carrageenan test, the crude extract reduced rat paw oedema by 9.8, 28.5 and 65.9%, respectively. For the histamine assay, the reductions of oedema were 70.1, 71.7 and 81.9%, respectively. In the myeloperoxidase (MPO) assay, 300 mg kg (-1) crude extract produced a significant inhibition of the MPO activity, at 6 h and 24 h after injection of carrageenan, by 42.8 and 46.2%, respectively. With the granulomatous tissue assay dexamethasone displayed significant activity, whereas the blueberry extract was inactive. For the abdominal constriction test, inhibitions of 49.0, 54.5, 53.5%, respectively, were observed for the crude extract, and 61.4% for indometacin. In the formalin test, the crude extract (200 and 300 mg kg (-1)) and indometacin inhibited only the second phase by 36.2, 35.3 and 45.8%, respectively. Considering that the crude extract of blueberry displayed antinociceptive and anti-inflammatory activity, its consumption may be helpful for the treatment of inflammatory disorders.

Publication types

  • Comparative Study

MeSH terms

  • Abdomen
  • Analgesics / administration & dosage
  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / pharmacology*
  • Carrageenan
  • Constriction, Pathologic / chemically induced
  • Constriction, Pathologic / drug therapy
  • Dexamethasone / pharmacology
  • Dose-Response Relationship, Drug
  • Edema / chemically induced
  • Edema / drug therapy*
  • Fruit
  • Granuloma, Foreign-Body / drug therapy
  • Histamine / physiology
  • Indomethacin / pharmacology
  • Male
  • Pain Measurement
  • Peroxidase / drug effects
  • Peroxidase / metabolism
  • Phytotherapy
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Vaccinium*

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Dexamethasone
  • Histamine
  • Carrageenan
  • Peroxidase
  • Indomethacin