Synthesis of perfluoroalkylated benzenes and pyridines through cationic Rh(I)/modified BINAP-catalyzed chemo- and regioselective [2 + 2 + 2] cycloaddition

Ken Tanaka; Hiromi Hara; Goushi Nishida; Masao Hirano

doi:10.1021/ol070456m

Synthesis of perfluoroalkylated benzenes and pyridines through cationic Rh(I)/modified BINAP-catalyzed chemo- and regioselective [2 + 2 + 2] cycloaddition

Org Lett. 2007 May 10;9(10):1907-10. doi: 10.1021/ol070456m. Epub 2007 Apr 14.

Authors

Ken Tanaka¹, Hiromi Hara, Goushi Nishida, Masao Hirano

Affiliation

¹ Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan. tanaka-k@cc.tuat.ac.jp

PMID: 17432866
DOI: 10.1021/ol070456m

Abstract

A convenient synthesis of perfluoroalkylated benzenes and pyridines has been achieved by a cationic Rh(I)/modified BINAP-complex-catalyzed chemo- and regioselective [2 + 2 + 2] cycloaddition of alkynes with a perfluoroalkylacetylene and a perfluoroalkylnitrile.