Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp

J Nat Prod. 2007 May;70(5):730-5. doi: 10.1021/np060389p. Epub 2007 Apr 14.


The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus Lyngbya, which was isolated from a periphyton mat from the Florida Everglades.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cyanobacteria / chemistry*
  • Florida
  • Fresh Water
  • Lyngbya Toxins / chemistry*
  • Molecular Structure
  • Peptides, Cyclic / chemistry*


  • Lyngbya Toxins
  • Peptides, Cyclic
  • pahayokolide A
  • pahayokolide B