Mutations within the FGF5 gene are associated with hair length in cats

Anim Genet. 2007 Jun;38(3):218-21. doi: 10.1111/j.1365-2052.2007.01590.x. Epub 2007 Apr 13.


Hereditary hair length variability in mice and dogs is caused by mutations within the fibroblast growth factor 5 (FGF5) gene. The aim of this study was to evaluate the feline FGF5 orthologue as a functional candidate gene for the long hair phenotype in cats, which is recessive to short hair. We amplified the feline FGF5 cDNA and characterised two alternatively spliced transcripts by RT-PCR. Comparative cDNA and genomic DNA sequencing of long- and short-haired cats revealed four non-synonymous polymorphisms in the FGF5 coding sequence. A missense mutation (AM412646:c.194C>A) was found in the homozygous state in 25 long-haired Somali, Persian, Maine Coon, Ragdoll and crossbred cats. Fifty-five short-haired cats had zero or one copy of this allele. Additionally, we found perfect co-segregation of the c.194C>A mutation within two independent pedigrees segregating for hair length. A second FGF5 exon 1 missense mutation (AM412646:c.182T>A) was found exclusively in long-haired Norwegian Forest cats. The c.182T>A mutation probably represents a second FGF5 mutation responsible for long hair in cats. In addition to the c.194C>A mutation, a frameshift mutation (AM412646:c.474delT) was found with a high frequency in the long-haired Maine Coon breed. Finally, a missense mutation (AM412646:c.475A>C) was also associated with the long-haired phenotype in some breeds. However, as one short-haired cat was homozygous for this polymorphism, it is unlikely that it has a functional role in the determination of hair length.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Base Sequence
  • Cats / genetics*
  • Fibroblast Growth Factor 5 / genetics*
  • Hair*
  • Molecular Sequence Data
  • Mutation, Missense / genetics*
  • Pedigree
  • Polymorphism, Genetic*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Analysis, DNA


  • Fibroblast Growth Factor 5