Apolipoprotein E gene epsilon2/epsilon3/epsilon4 polymorphism and myocardial infarction: case-control study in a large population sample

Int J Cardiol. 2008 Mar 28;125(1):116-7. doi: 10.1016/j.ijcard.2007.01.012. Epub 2007 Apr 11.


It has not been clearly established yet whether the epsilon2/epsilon3/epsilon4 polymorphism of the gene encoding apolipoprotein E is associated with myocardial infarction. We addressed this issue in a large case-control sample and found no statistically significant relationship between the epsilon2/epsilon3/epsilon4 polymorphism and myocardial infarction. The epsilon2 allele and epsilon2epsilon3 genotype showed trends towards lower risks of myocardial infarction than the epsilon3epsilon3 genotype.

Publication types

  • Letter

MeSH terms

  • Apolipoprotein E2 / genetics
  • Apolipoprotein E3 / genetics
  • Apolipoprotein E4 / genetics
  • Apolipoproteins E / genetics*
  • Case-Control Studies
  • Genotype
  • Humans
  • Myocardial Infarction / genetics*
  • Polymorphism, Genetic*
  • Risk Factors


  • Apolipoprotein E2
  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E