Paraoxonase, total antioxidant activity and peroxide levels in marasmic children: relationships with leptin

Clin Biochem. 2007 Jun;40(9-10):634-9. doi: 10.1016/j.clinbiochem.2007.03.001. Epub 2007 Mar 16.

Abstract

Objectives: The aim of this study was to investigate the oxidant/antioxidant status, paraoxonase (PON) activity and leptin levels in children with marasmic malnutrition.

Design and methods: Thirty marasmic children (age 14.4+/-10.3 months) and 28 control subjects were included. Plasma PON activity, total antioxidant activity (TAO), total peroxide (TPX) and leptin levels were measured.

Results: Malnourished children had significantly lower leptin (3.6+/-1.1 vs. 11.8+/-4.5 ng/mL, P<0.001), PON activity (66.4+/-28.6 vs. 221.3+/-31.6 IU/L, P<0.001) and TAO (1.44+/-0.12 vs. 2.45+/-0.61 mmol Trolox equiv/L, P<0.001); and higher TPX (15.6+/-6.4 vs. 5.9+/-1.9 micromol/L, P<0.001) values than in controls. Significant negative correlation was found between PON and TPX (P=0.040) and positive correlation between TAO and BMI (P=0.034) in patients. No significant correlation was found between leptin and oxidant/antioxidant parameters (P>0.05).

Conclusions: Children with marasmic malnutrition had increased pro-oxidant and decreased antioxidant status. Extent of oxidative stress increases with malnutrition severity. Antioxidants could be given during nutritional rehabilitation.

Publication types

  • Evaluation Study

MeSH terms

  • Antioxidants / analysis*
  • Aryldialkylphosphatase / blood*
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Leptin / blood*
  • Lipids / blood
  • Male
  • Oxidative Stress / physiology
  • Peroxides / blood*
  • Protein-Energy Malnutrition / physiopathology*

Substances

  • Antioxidants
  • Leptin
  • Lipids
  • Peroxides
  • Aryldialkylphosphatase