Thymoma-associated multiorgan autoimmunity: a graft-versus-host-like disease

J Am Acad Dermatol. 2007 Oct;57(4):683-9. doi: 10.1016/j.jaad.2007.02.027. Epub 2007 Apr 16.


Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations similar to that seen in GVHD. We also review other reported cases of GVHD-like manifestations in the setting of thymoma and propose "thymoma-associated multiorgan autoimmunity" as a name for this novel disease. Specifically, thymoma-associated multiorgan autoimmunity is defined as a disease of the liver, intestine, or skin, which on histopathology resembles GVHD but is seen in the setting of malignant thymoma and not after hematopoietic stem cell transplantation.

Publication types

  • Case Reports

MeSH terms

  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / immunology*
  • Diagnosis, Differential
  • Graft vs Host Disease / diagnosis
  • Graft vs Host Disease / immunology*
  • Humans
  • Male
  • Middle Aged
  • Paraneoplastic Syndromes / immunology*
  • Thymoma / complications
  • Thymoma / immunology*
  • Thymoma / surgery
  • Thymus Neoplasms / complications
  • Thymus Neoplasms / immunology*
  • Thymus Neoplasms / surgery