Differential effects of aging on activin A and its binding protein, follistatin, across the menopause transition

Fertil Steril. 2007 Oct;88(4):1003-5. doi: 10.1016/j.fertnstert.2006.12.009. Epub 2007 Apr 16.


To assess the involvement of ovarian-derived regulatory proteins in FSH modulation, we compared FSH, inhibin A, inhibin B, activin A, and follistatin (FS) in 79 women from the following five groups: young cycling, older cycling, perimenopause (PERI), spontaneous menopause (PM), and surgical menopause receiving estrogen (OVX+ET). Although inhibin B varied as expected by ovarian function, no group differences were observed in activin A, barring a tendency for an increase in PERI, while FS 288 was lower in the PERI, PM, and OVX+ET groups and negatively correlated with advancing age.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activins / physiology*
  • Adult
  • Aging / physiology*
  • Cross-Sectional Studies
  • Female
  • Follicle Stimulating Hormone / metabolism
  • Follistatin / physiology*
  • Humans
  • Inhibins / physiology
  • Menopause / physiology*
  • Middle Aged
  • Ovariectomy


  • FST protein, human
  • Follistatin
  • activin A
  • inhibin A
  • inhibin B
  • Activins
  • Inhibins
  • Follicle Stimulating Hormone