Abstract
We have identified a gene that, when present in multiple copies, partially inhibits nuclear protein localization in Saccharomyces cerevisiae. This gene encodes a protein that is a unique member of the Cys2His2 zinc-finger family of DNA-binding proteins. It is designated SFP1 for split finger protein because its two zinc-finger domains are separated from one another by 40 amino acids (aa) as opposed to the usual spacing of 7 or 8 aa for Cys2His2 proteins. Disruption of the SFP1 gene results in slow cell growth, with cells having multiple, nucleated buds.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Base Sequence
-
Blotting, Northern
-
Cloning, Molecular
-
DNA-Binding Proteins / genetics*
-
Fluorescent Antibody Technique
-
Fungal Proteins / analysis
-
Fungal Proteins / genetics
-
Gene Expression / genetics
-
Genes, Fungal / genetics*
-
Molecular Sequence Data
-
Nuclear Proteins / analysis
-
Recombinant Fusion Proteins / genetics
-
Restriction Mapping
-
Saccharomyces cerevisiae / genetics
-
Saccharomyces cerevisiae / growth & development*
-
Saccharomyces cerevisiae Proteins*
-
Zinc Fingers / genetics*
Substances
-
DNA-Binding Proteins
-
Fungal Proteins
-
Nuclear Proteins
-
Recombinant Fusion Proteins
-
SFP1 protein, S cerevisiae
-
Saccharomyces cerevisiae Proteins
Associated data
-
GENBANK/M59726
-
GENBANK/M59727
-
GENBANK/M59728
-
GENBANK/M63577
-
GENBANK/S66195
-
GENBANK/S66202
-
GENBANK/S66205
-
GENBANK/S66209
-
GENBANK/S66212
-
GENBANK/S68557