Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin

Genetics. 2007 Jun;176(2):1355-8. doi: 10.1534/genetics.107.073676. Epub 2007 Apr 15.

Abstract

In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(var)3-1[3]) allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Chromatin / genetics
  • Chromosome Mapping
  • DNA / genetics*
  • Drosophila / genetics*
  • Drosophila Proteins / genetics*
  • Gene Silencing
  • Genes, Reporter
  • Heterochromatin / genetics*
  • Loss of Heterozygosity / genetics*
  • Protein-Serine-Threonine Kinases / genetics*
  • Sequence Deletion

Substances

  • Chromatin
  • Drosophila Proteins
  • Heterochromatin
  • DNA
  • JIL-1 protein, Drosophila
  • Protein-Serine-Threonine Kinases