Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Nat Genet. 2007 May;39(5):593-5. doi: 10.1038/ng2025. Epub 2007 Apr 15.


We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation / genetics*
  • Cell Differentiation / immunology
  • Cell Line, Tumor
  • Chromosomes, Artificial / genetics
  • Flow Cytometry
  • Gene Dosage
  • Gene Duplication*
  • Gene Expression Regulation, Neoplastic / genetics
  • Genes, myb / genetics*
  • Genetic Testing
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia-Lymphoma, Adult T-Cell / genetics*
  • Mutation / genetics
  • Nucleic Acid Hybridization / genetics
  • RNA, Small Interfering / genetics
  • Statistics, Nonparametric
  • T-Lymphocytes / pathology*


  • RNA, Small Interfering