Immunopathogenesis of respiratory syncytial virus bronchiolitis

J Infect Dis. 2007 May 15;195(10):1532-40. doi: 10.1086/515575. Epub 2007 Apr 12.


Background: The objective of this study was to elucidate the relation between respiratory syncytial virus (RSV) infection and cytokine/chemokine concentrations, as well as the impact that these factors have on the severity of bronchiolitis.

Methods: Children <24 months old who presented to the emergency department with clinical symptoms of bronchiolitis were prospectively enrolled in the study. Nasal-wash samples were analyzed to identify viral pathogens and to quantify RSV and cytokine/chemokine concentrations. Severe cases of disease were defined as those requiring hospitalization, and severity was further determined on the basis of the duration of supplemental-oxygen and/or intravenous-fluid therapy.

Results: A total of 101 children were enrolled, 63 of whom were infected with RSV and 13 of whom were infected with other respiratory viruses; in 22 children, no virus was detected. RSV bronchiolitis was associated with a greater inflammatory response than was non-RSV bronchiolitis, although RSV infection was not associated with more-severe disease. Levels of interleukin (IL)-6, IL-8, IL-10, interferon (IFN)-gamma, and macrophage inflammatory protein (MIP)-1beta were significantly inversely correlated with the duration of supplemental-oxygen therapy.

Conclusion: The robust inflammatory response associated with RSV infection does not contribute to the severity of RSV bronchiolitis any more than it contributes to the severity of non-RSV bronchiolitis. Elevated levels of proinflammatory mediators IL-6, IL-8, IFN-gamma, and MIP-1beta, as well as of the regulatory cytokine IL-10, may be protective against hypoxia in bronchiolitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchiolitis / immunology
  • Bronchiolitis / pathology
  • Bronchiolitis / virology
  • Chemokines / analysis
  • Cytokines / analysis
  • Female
  • Genetic Predisposition to Disease
  • Heart Defects, Congenital / complications
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Nasal Mucosa / physiopathology
  • Prospective Studies
  • Respiratory Syncytial Virus Infections / immunology*
  • Respiratory Syncytial Virus Infections / pathology
  • Respiratory Syncytial Viruses / genetics*
  • Respiratory Syncytial Viruses / immunology*
  • Respiratory Syncytial Viruses / isolation & purification
  • Respiratory Tract Infections / virology


  • Chemokines
  • Cytokines