Role of Tribulus terrestris (Linn.) (Zygophyllacea) against mercuric chloride induced nephrotoxicity in mice, Mus musculus (Linn.)

J Environ Biol. 2006 May;27(2 Suppl):397-400.


The present study investigates the influence of methanolic fraction (MF) of Tribulus terrestris fruit extract on the kidney tissues of mercury intoxicated mice, Mus musculus. At median-lethal dose of mercuric chloride (12.9 mg/kg body weight), the whole kidney tissue showed an increased level of lipid peroxidation (LPO), glutathione peroxidase (GPx) activities and simultaneously a decreased level of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH). These parameters reached to near normal after administration of fruit extracts of T. terrestris for 7 days. The results suggested that the oral administration of methanolic fraction of Tribulus terrestris fruit extract at dose 6 mg/kg body weight provided protection against the mercuric chloride induced toxicity in the mice.

MeSH terms

  • Animals
  • Catalase / metabolism
  • Female
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Kidney / drug effects*
  • Lethal Dose 50
  • Lipid Peroxidation
  • Mercuric Chloride / toxicity*
  • Mice
  • Plant Extracts / pharmacology*
  • Superoxide Dismutase / metabolism
  • Zygophyllaceae / chemistry*


  • Plant Extracts
  • Mercuric Chloride
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione