Alcohol consumption, cigarette smoking, and endometrial cancer risk: results from the Netherlands Cohort Study

Cancer Causes Control. 2007 Jun;18(5):551-60. doi: 10.1007/s10552-007-0127-x. Epub 2007 Apr 16.


Objective: To examine the association between alcohol consumption, cigarette smoking, and endometrial cancer.

Methods: In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women. Follow-up for cancer was established by record linkage to the Netherlands Cancer Registry.

Results: After 11.3-years of follow-up, 280 incident endometrial cancer cases were available for analyses. In multivariate analysis, the rate ratio (RR) for alcohol users versus non-users was 1.06 (95% Confidence Interval (95% CI)=0.78-1.43). There were neither dose-dependent trends nor associations with different types of beverages. The RR for former and current smokers versus never-smokers was 0.83 (95% CI=0.58-1.20) and 0.59 (95% CI=0.40-0.88), respectively. These estimates did not change significantly when body mass index (BMI) and age at menopause were added to the models.

Conclusions: There is no association between alcohol consumption and endometrial cancer. Current smoking is associated with a reduced risk of endometrial cancer. This association is neither mediated by BMI nor by age at menopause.

MeSH terms

  • Aged
  • Alcohol Drinking / adverse effects*
  • Body Mass Index
  • Cohort Studies
  • Contraceptives, Oral / pharmacology
  • Endometrial Neoplasms / etiology*
  • Female
  • Humans
  • Menopause
  • Middle Aged
  • Risk Factors
  • Smoking / adverse effects*


  • Contraceptives, Oral