PLK1 inhibitors: setting the mitotic death trap

Curr Biol. 2007 Apr 17;17(8):R280-3. doi: 10.1016/j.cub.2007.02.018.

Abstract

Polo-like kinase 1 (Plk1) regulates mitotic progression in all eukaryotes and has been implicated in the transformation of human cells. Analysis of the cytological and anti-tumor activities of BI 2536, a novel, selective pharmacological inhibitor of Plk1, has connected chemistry and biology to the bedside.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Cell Cycle Proteins / antagonists & inhibitors*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Mitosis / drug effects*
  • Neoplasms / drug therapy*
  • Polo-Like Kinase 1
  • Protein Serine-Threonine Kinases / antagonists & inhibitors*
  • Proto-Oncogene Proteins / antagonists & inhibitors*
  • Pteridines / pharmacology*
  • Pteridines / therapeutic use

Substances

  • Antineoplastic Agents
  • BI 2536
  • Cell Cycle Proteins
  • Enzyme Inhibitors
  • Proto-Oncogene Proteins
  • Pteridines
  • Protein Serine-Threonine Kinases