Prophylactic effect of dietary seaweed Fucoidan against enteral prion infection

Antimicrob Agents Chemother. 2007 Jun;51(6):2274-7. doi: 10.1128/AAC.00917-06. Epub 2007 Apr 16.

Abstract

Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral*
  • Animals
  • Cattle
  • Cell Line, Tumor
  • Diet
  • Fucose
  • Humans
  • Phytotherapy
  • Polysaccharides / administration & dosage
  • Polysaccharides / chemistry
  • Polysaccharides / therapeutic use*
  • PrPSc Proteins / administration & dosage*
  • PrPSc Proteins / pathogenicity
  • Prion Diseases / prevention & control*
  • Prions
  • Scrapie / prevention & control
  • Seaweed / chemistry*

Substances

  • Polysaccharides
  • PrPSc Proteins
  • Prions
  • Fucose
  • fucoidan