Prospects for the use of NK cells in immunotherapy of human cancer

Nat Rev Immunol. 2007 May;7(5):329-39. doi: 10.1038/nri2073.


Current insights into the molecular specificities that regulate natural killer (NK)-cell function suggest that it might be possible to design NK-cell-based immunotherapeutic strategies against human cancer. Here, we describe evidence for NK-cell targeting of human tumours and address crucial questions that, in our opinion, require consideration for the development of successful NK-cell-based therapies. Appropriately used, we predict that NK cells will have a role, both directly and in combination with other treatment modalities, in future treatment of cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunotherapy / methods*
  • Killer Cells, Natural / immunology*
  • Models, Immunological*
  • Neoplasms / therapy*