New developments in FcepsilonRI regulation, function and inhibition

Nat Rev Immunol. 2007 May;7(5):365-78. doi: 10.1038/nri2072.


The high-affinity Fc receptor for IgE (FcepsilonRI), a multimeric immune receptor, is a crucial structure for IgE-mediated allergic reactions. In recent years, advances have been made in several important areas of the study of FcepsilonRI. The first area relates to FcepsilonRI-mediated biological responses that are antigen independent. The second area encompasses the biological relevance of the distinct signalling pathways that are activated by FcepsilonRI; and the third area relates to the accumulated evidence for the tight control of FcepsilonRI signalling through a broad array of inhibitory mechanisms, which are being developed into promising therapeutic approaches.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Hypersensitivity / immunology*
  • Models, Immunological*
  • Receptors, IgE*
  • Signal Transduction / immunology*


  • MS4A2 protein, human
  • Receptors, IgE