Treatment outcome cohort analysis in an integrated DOTS and DOTS-Plus TB program in Latvia

Int J Tuberc Lung Dis. 2007 May;11(5):585-7.


International guidelines for treatment outcome analysis of tuberculosis cases have been published and are widely used. They do not, however, fully address the incorporation of multidrug-resistant tuberculosis (MDR-TB) cases. Here we present an approach to cohort analysis of treatment outcomes for all registered TB cases, including MDR-TB cases. We analyzed all new pulmonary smear- and/or culture-positive cases registered in Latvia during 2002. Analysis of treatment outcomes at 24 months after initial case registration showed overall treatment success at 84%. This approach to outcome analysis is possible only for settings where MDR-TB treatment is established.

MeSH terms

  • Antitubercular Agents / administration & dosage*
  • Cohort Studies
  • Directly Observed Therapy / methods*
  • Humans
  • Latvia
  • Program Evaluation
  • Treatment Outcome
  • Tuberculosis / drug therapy*
  • Tuberculosis / mortality
  • Tuberculosis, Multidrug-Resistant / drug therapy*
  • Tuberculosis, Multidrug-Resistant / mortality


  • Antitubercular Agents