Effects of motor cortex rTMS on lower urinary tract dysfunction in multiple sclerosis

Mult Scler. 2007 Mar;13(2):269-71. doi: 10.1177/1352458506070729. Epub 2007 Jan 29.


We tested the effects of 5-Hz rTMS over the motor cortex in multiple sclerosis (MS) subjects complaining of lower urinary tract symptoms either in the filling or voiding phase. Our data show that motor cortex stimulation for five consecutive days over two weeks ameliorates the voiding phase of the micturition cycle, suggesting that enhancing corticospinal tract excitability might be useful to ameliorate detrusor contraction and/or urethral sphincter relaxation in MS patients with bladder dysfunction.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Cortex / physiology
  • Multiple Sclerosis / complications*
  • Pyramidal Tracts / physiology
  • Transcranial Magnetic Stimulation*
  • Treatment Outcome
  • Urinary Bladder, Overactive / etiology
  • Urinary Bladder, Overactive / physiopathology
  • Urinary Bladder, Overactive / therapy*
  • Urination Disorders / etiology
  • Urination Disorders / physiopathology
  • Urination Disorders / therapy*