Highway to the inner nuclear membrane: rules for the road

Nat Rev Mol Cell Biol. 2007 May;8(5):414-20. doi: 10.1038/nrm2165. Epub 2007 Apr 18.


To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins. Here we develop a set of rules that might govern the transport of proteins to the inner nuclear membrane.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology*
  • Animals
  • Cell Nucleus / metabolism*
  • Humans
  • Karyopherins / physiology
  • Models, Biological
  • Nuclear Envelope / physiology*
  • Nuclear Localization Signals / physiology
  • Nuclear Pore / physiology
  • Nuclear Pore Complex Proteins / physiology
  • Protein Transport / physiology


  • Karyopherins
  • Nuclear Localization Signals
  • Nuclear Pore Complex Proteins