Putting evidence into practice: evidence-based interventions to prevent, manage, and treat chemotherapy-induced nausea and vomiting

Clin J Oncol Nurs. 2007 Feb;11(1):69-78. doi: 10.1188/07.CJON.69-78.


Chemotherapy-induced nausea and vomiting (CINV) continues to have a considerable effect on the physical and psychological well-being of patients with cancer, despite significant advances in antiemetic drugs since the 1990s. This article reviews and summarizes past and current empirical evidence related to interventions for CINV. A resource that summarizes evidence-based interventions for CINV is critical for effective management of this distressing symptom. Pharmacologic and nonpharmacologic interventions are appraised. Finally, gaps in the literature and opportunities for research, education, and practice changes are discussed.

Publication types

  • Review

MeSH terms

  • Antiemetics / therapeutic use
  • Antineoplastic Agents / adverse effects*
  • Benchmarking
  • Evidence-Based Medicine / organization & administration*
  • Health Services Needs and Demand
  • Humans
  • Nausea* / chemically induced
  • Nausea* / prevention & control
  • Nurse's Role
  • Nursing Research / organization & administration*
  • Oncology Nursing / organization & administration*
  • Outcome Assessment, Health Care
  • Patient Care Planning
  • Patient Education as Topic / organization & administration
  • Practice Guidelines as Topic
  • Primary Prevention
  • Relaxation Therapy
  • Serotonin Antagonists
  • Vomiting* / chemically induced
  • Vomiting* / prevention & control


  • Antiemetics
  • Antineoplastic Agents
  • Serotonin Antagonists