Multiple myeloma is commonly associated with bony lesions and skeletal destruction. Percutaneous vertebroplasty (PVP) was performed in five patients with multiple myeloma for vertebral body fractures. Four patients reported a decrease in their pain after the procedure, and in all patients an improvement in their performance status could be noted. Complications included fever in two patients. PVP can be safely and effectively performed in patients with vertebral body fractures caused by multiple myeloma.