Proposal of an algorithm for diagnosis and treatment of neonatal seizures in developing countries

Epilepsia. 2007 Jun;48(6):1158-64. doi: 10.1111/j.1528-1167.2007.01008.x. Epub 2007 Apr 18.


Seizures in the neonatal period are common. They can be caused by a variety of conditions, ranging from benign, self-limited illnesses to severe, life-threatening disorders. They are often the first sign of neurologic dysfunction in neonates, and may be used as one factor in considering long-term prognosis. An important mission of the International League Against Epilepsy (ILAE) is to improve the care of patients with epilepsy. Most recently, as part of the Global Campaign against Epilepsy, ILAE, in conjunction with the World Health Organization (WHO), established a new initiative to create clinical guidelines and diagnostic and management algorithms for the care of patients with seizures that can be applied worldwide, including in developing countries with limited or varied medical resources. Created by an international panel of experts in seizure management and guideline development, this document proposes guidelines for the diagnosis and management of the most common and important conditions that cause seizures in the neonatal period. The publication of these clinical pathways for neonatal seizures will be followed by a period of field testing and comment by WHO clinicians and officials before finalization.

MeSH terms

  • Algorithms*
  • Anticonvulsants / therapeutic use
  • Developing Countries*
  • Epilepsy, Benign Neonatal / diagnosis*
  • Epilepsy, Benign Neonatal / therapy*
  • Female
  • Global Health
  • Humans
  • Infant, Newborn
  • International Agencies / standards
  • International Cooperation
  • Patient Care Management / methods*
  • Patient Care Management / standards
  • Practice Guidelines as Topic
  • Pregnancy
  • Prognosis
  • World Health Organization


  • Anticonvulsants