Birth after intracytoplasmic sperm injection with use of testicular sperm from men with Kartagener or immotile cilia syndrome

Fertil Steril. 2007 Aug;88(2):497.e9-11. doi: 10.1016/j.fertnstert.2006.11.113. Epub 2007 Apr 17.


Objective: To describe a case of intracytoplasmic sperm injection (ICSI) with testicular sperm in men with immotile cilia syndrome and to discuss the role of micromanipulation in the treatment of these patients.

Design: Case report.

Setting: Private infertility clinic and assisted reproduction unit.

Patient(s): Couple with male factor infertility due to Kartagener's/immotile cilia syndrome.

Intervention(s): The patient's partner underwent ICSI with testicular sperm.

Main outcome measure(s): Semen characteristics, sperm viability, fertilization and cleavage rate, pregnancy, and birth after ICSI.

Result(s): With testicular sperm, the two pronuclear fertilization rates were 53%. ICSI was successful in the first cycle. The uncomplicated pregnancy resulted in the birth of two healthy children, male/female twins.

Conclusion(s): With testicular sperm, successful oocyte fertilization after ICSI in couples with male Kartagener or immotile cilia syndrome is possible with nonprogressive motile sperm resulting in clinically healthy offsprings.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Ciliary Motility Disorders / pathology*
  • Female
  • Humans
  • Infant, Newborn
  • Kartagener Syndrome / pathology*
  • Male
  • Parturition*
  • Pregnancy
  • Pregnancy, Multiple
  • Sperm Injections, Intracytoplasmic*
  • Spermatozoa / pathology*
  • Twins