A framework for quality control and parameter optimization in diffusion tensor imaging: theoretical analysis and validation

Magn Reson Imaging. 2007 Oct;25(8):1196-202. doi: 10.1016/j.mri.2007.02.011. Epub 2007 Apr 18.


In this communication, a theoretical framework for quality control and parameter optimization in diffusion tensor imaging (DTI) is presented and validated. The approach is based on the analytical error propagation of the mean diffusivity (D(av)) obtained directly from the diffusion-weighted data acquired using rotationally invariant and uniformly distributed icosahedral encoding schemes. The error propagation of a recently described and validated cylindrical tensor model is further extrapolated to the spherical tensor case (diffusion anisotropy approximately 0) to relate analytically the precision error in fractional tensor anisotropy (FA) with the mean diffusion-to-noise ratio (DNR). The approach provided simple analytical and empirical quality control measures for optimization of diffusion parameter space in an isotropic medium that can be tested using widely available water phantoms.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms*
  • Brain / anatomy & histology*
  • Computer Simulation
  • Diffusion Magnetic Resonance Imaging / instrumentation
  • Diffusion Magnetic Resonance Imaging / methods*
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Models, Neurological*
  • Phantoms, Imaging
  • Quality Assurance, Health Care / methods
  • Quality Control
  • Reproducibility of Results
  • Sensitivity and Specificity