Buffering capacities of goat milk (Alpine, Nubian), cow milk (Holstein, Jersey), soy-based infant formulas, and non-prescription antacid drugs were estimated. Total N, protein, NPN, and P2O5 as major buffering entities were quantified for each milk category. Nubian goat milk had the highest levels of the three major buffering chemical entities, and the infant formulas contained less total N and NPN compared with natural goat and cow milks. Buffering capacities of the formulas also were lower than those of natural milks. Combinations of milk and antacid drugs had higher buffering capacities than either the milk or drug alone. Drug plus goat milk combinations upon addition of more than 2 ml of acid titrant exhibited fewer changes in pH than the respective drug plus cow milk combinations.