A case report of simultaneous thrombosis of two coronary artery stents in association with clopidogrel resistance

Clin Cardiol. 2007 Apr;30(4):200-3. doi: 10.1002/clc.9.


Despite aggressive antiplatelet therapy in the setting of PCI, the incidence of acute stent thrombosis remains approximately 0.5-2%. We report a patient with simultaneous thrombosis of two drug-eluting coronary artery stents, suggesting a systemic thrombotic state. Evaluation by optical platelet aggregometry revealed clopidogrel resistance, which was overcome at a higher drug dose. We aim to highlight the potential utility of platelet function analysis to guide therapy for patients in whom inadequate antiplatelet therapy may have catastrophic clinical outcomes.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary
  • Clopidogrel
  • Coronary Stenosis / therapy
  • Coronary Thrombosis / etiology*
  • Coronary Thrombosis / physiopathology
  • Drug Resistance / drug effects
  • Humans
  • Male
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Platelet Function Tests
  • Stents / adverse effects*
  • Ticlopidine / analogs & derivatives*
  • Ticlopidine / therapeutic use


  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Ticlopidine