Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Apr;69 Suppl 1:58-60.
doi: 10.1111/j.1399-0039.2006.760_3.x.

The Identification and Characterisation of a Novel Null HLA-DRB1 Allele

Affiliations

The Identification and Characterisation of a Novel Null HLA-DRB1 Allele

S J Fidler et al. Tissue Antigens. .

Abstract

Since the introduction of DNA-based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this abstract (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.

Similar articles

See all similar articles

LinkOut - more resources

Feedback